ea0016p444 | Neuroendocrinology | ECE2008
Hallschmid Manfred
, Bendict Christian
, Spielmann Sophie
, Schicke Rick
, Kern Werner
, Born Jan
, Lehnert Hendrik
Introduction: In elderly humans sleep disturbances are associated with an impaired nocturnal inhibition of the hypothalamopituitaryadrenal (HPA) axis and chronic diseases like metabolic syndrome and depression. Recent experiments in young and healthy subjects demonstrated that intranasal ANP inhibited stimulated cortisol secretion during wakefulness whereas administration of intranasal insulin in the evening reduced cortisol levels in the morning after undisturbed ...